XEMSIT DM 500 is combination of Sitagliptin 100 mg + Dapagliflozin 10 mg + Metformin 500 mg & is used in the treatment of Type 2 diabetes mellitus.Sitagliptin helps control blood sugar levels by increasing substances (incretins) in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar (glucose) when there is too much sugar in the blood.Dapagliflozin increases urinary glucose excretion and reduces blood glucose levels. Metformin decreases the amount of glucose you absorb from the food and the amount of glucose made by the liver. Metformin also increases the body’s response to insulin, a natural substance that controls the amount of glucose in the blood.